Your best bet for the list of différence would be to watch the Feature Premiere of the BallPlayer feature on YouTube. It will explain how it is working now.
Lonng Story Short RTTS is now linked with DD, which means it is not a pure offline mode anymore.
You can have multiple saves BUT only ONE Player. So if you start all over, you'll be keeping all the stats/traits of your first player.
All attributes are capped at 50 and other attributes are unlocked with Cards you get in packs/progression that you pick before each games. So basically Game 1 you have Speed 85+ and Power in the 60's and the mext day speed is now 41 and Power 83 because you loaded différent cards... (I know it's dumb but that's what they did)
No More personality perks
No more archetype to pick at the start
No more "Training/evaluation" at the start, you start at the draft directly
You can't change the sliders or you'll lose progression. (I used to turn trades to the minimum but now I can't and I have to live with the bonehead moove my virtual GM is making)
You are forced to be a 2-way player at the start. You can't decide to be only a position player. You'll have to pitch a few games even if you hate it... Same goes if you want to be a pitcher, you'll have to be a position player for a few games.
They made a podcast with people commenting your career... It's pointless, I've skipped nearly all of them...
It's built to funnel you into DD play and hopefully spend $$$ on the game...
There are the differences I noted... Sorry...